Authorities confirmed Wednesday that a light plane from Embry-Riddle Aeronautical University crashed shortly after take-off late that morning.
According to accounts from investigators, the plane went down near Daytona Beach, close to a local Flea and Farmer's market.
Officials with the university said that a student plot and a designated Federal Aviation Administration pilot examiner were the only people onboard.
Neither person survived the crash, investigators said.
There did not appear to be any other casualties, according to authorities.
The Volusia County Sheriff's Office said it has notified federal investigators, notably the National Transportation Safety Administration and Federal Aviation Administration, so that they could begin their own crash investigations.
The president of Embry-Riddle said that the deepest sympathies of those at the university were with all who were affected by the loss of life in the accident.
The president added that the university would cooperate fully in the investigation.